Contribution of Clumping Factor B to Pathogenesis of Experimental Endocarditis due to Staphylococcus aureus
نویسندگان
چکیده
منابع مشابه
Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus.
Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experime...
متن کاملRole of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis.
The pathogenic role of staphylococcal coagulase and clumping factor was investigated in the rat model of endocarditis. The coagulase-producing and clumping factor-producing parent strain Staphylococcus aureus Newman and a series of mutants defective in either coagulase, clumping factor, or both were tested for their ability (i) to attach in vitro to either rat fibrinogen or platelet-fibrin clot...
متن کاملEfficacy of garenoxacin in treatment of experimental endocarditis due to Staphylococcus aureus or viridans group streptococci.
The activity of garenoxacin was investigated in rats with experimental endocarditis due to staphylococci and viridans group streptococci (VGS). The staphylococci tested comprised one ciprofloxacin-susceptible and methicillin-susceptible Staphylococcus aureus (MSSA) isolate (isolate 1112), one ciprofloxacin-susceptible but methicillin-resistant S. aureus (MRSA) isolate (isolate P8), and one cipr...
متن کاملEndocarditis due to Staphylococcus aureus after minor dog bite.
Living in a society of animal lovers, the dangers are often not always apparent. Injury from bites and scratches is an occupational hazard for those people who work with animals. Despite the high risk of secondary wound infection as a result of an animal bite, many patients do not receive treatment with an antimicrobial medication. This report describes a case of a previously fit and well 66-ye...
متن کاملStaphylococcus aureus mitral valve endocarditis due to heel decubitus ulcer.
DESCRIPTION Bacteraemic infections caused by Staphylococcus aureus have been reported with increasing frequency, and have emerged as the leading cause of infective endocarditis in many regions of the world. Endocarditis is an inflammation of the inner layer of the heart, the endocardium, with involvement of the heart valves (native or prosthetic valves). Other structures that may be involved in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2000
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.68.9.5443-5446.2000